A growing body of evidence suggests that EEG analyses, including both resting state and event-related stimulation protocols, are useful in the development of Biomarkers for a number of neurological and psychiatric disorders. EEG Biomarkers are also used to characterize brain responses to drugs.
The objective of the study was to validate attention and memory tasks that elicit event-related potentials (ERPs) for utility as sensitive biomarkers for early and advanced dementia. The results of the study comparing MCI and closely matched controls suggests that the ERP tasks administered concurrently with EEG are sensitive and reliable measures for cognitive decline and mild dementia. In particular, the ERPs elicited in response to the image recognition task represent a robust dementia biomarker that reflects the memory deficits in early dementia and has strong potential for utility in monitoring the efficacy of investigational, disease-modifying interventions.
64-year-old male Dx: amnestic MCI
• Theta-to-Alpha ratio (TAR) increased
• LPP component in SIR task decreased
